Time lords

The time lords--measurement and performance in sprinting.

T he modern Olympic Games were founded by Baron Pierre de Coubertin in 1896, with the intention of improving health and education, promoting world peace, and encouraging fair and equal competition. Such Victorian values, although inherently ennobling have little resonance in modern sport. The motto of the modern Olympic games—Citius, Altius, Fortius (swifter, higher, stronger)—illustrates how w...

Lords' Debate Problem of Leisure

WHEN Baroness Burton of Coventry rose in the House of Lords on Wednesday, May 13th, 1964, to call attention to the problem of leisure, she reminded the House of a debate during the previous month on the need for an increase of automation in British industry and commerce, and for effective planning to meet the inevitable changes which it would cause in our society. She said that in 1957, she had...

BH3-only proteins: the lords of death.

Although the mechanisms by which Bcl-2 family proteins control the apoptotic machinery of the cell are not fully understood, it becomes clear that the role of BH3-only proteins consists in serving as sensors or sentinels of cellular damage, transducing the apoptotic stimuli to the mitochondria. For this reason, mammalian cells have developed several strategies for their strict regulation throug...

AAA Proteins: Lords of the Ring

AAA ATPases (those associated with various cellular activities) 1 play important roles in numerous cellular activities including proteolysis, protein folding, membrane trafficking, cytoskeletal regulation, organelle biogenesis, DNA replication, and intracellular motility. Recent structural and enzymatic studies are providing clues into the properties of the conserved AAA domain that defines thi...

Debate in the House of Lords